Availability of tolerated and relatively safe antidepressants increased the use of antidepressants in late-life depression. However, only one-third of depressed older adults achieve remission with any single agent.1 Treatment resistance to antidepressants prompted the development and investigation of effective psychotherapies for cognitively unimpaired, depressed older adults. The common comorbidities of late-life depression led to novel psychotherapies for depressed patients with cognitive impairment, disability, chronic medical illnesses, or acute medical events. The selection and planning of psychotherapy depends on the patient’s clinical state and requires a thorough assessment. Areas of assessment include not only the patient’s depressive symptoms, acute and chronic stressors, interpersonal context, skills, and behavioral deficits, but also the presence and degree of the patient’s cognitive deficits, medical burden, and disability. This article describes assessment procedures pertinent to psychosocial interventions and outlines psychosocial interventions for depressed older adults.